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Applied Biosystems™ 3500 Dx Genetic Analyzer and Applied Biosystems™ 3500xL Dx Genetic Analyzer


Description:

Applied Biosystems™ 3500 Dx Genetic Analyzer and Applied Biosystems™ 3500xL Dx Genetic Analyzer by Life Technologies Corporation

The Applied Biosystems™ 3500 Dx Genetic Analyzer and Applied Biosystems™ 3500xL Dx Genetic Analyzer, produced by Life Technologies Corporation, are high-tech devices designed for performing capillary electrophoresis, a method essential in genetic research and diagnostics. These are remarkably advanced genetic analyzers offering immense benefits and efficiency in epidemiological studies, forensic analyses, and genetic disease research.

Primary Use

The key utility of these analyzers is to perform Sanger sequencing and fragment analysis, which make it possible to unveil the sequence of nucleotides in DNA. By discerning this genetic information, professionals gain essential insights that can inform a wide variety of health-related investigations. This might range from identifying a genetic disorder in a patient, discerning the genetic basis of a disease, or studying mutations linked to cancer progression.

Benefits

The Applied Biosystems™ 3500 and 3500xL Dx Genetic Analyzers present several advantages:

Overall, the Applied Biosystems™ 3500 Dx Genetic Analyzer and Applied Biosystems™ 3500xL Dx Genetic Analyzer are powerful, user-friendly, and precision-focused tools, indispensable for any laboratory engaged in genetics and molecular biology research.


Primary Use:

Applied Biosystems™ 3500 Dx and 3500xL Dx Genetic Analyzers


The Applied Biosystems™ 3500 Dx and 3500xL Dx Genetic Analyzers are highly advanced, valuable instruments used by medical professionals worldwide. These devices fall under the category of sequencers, which are essential for genetic analysis.

Primary Medical Use
Their primary medical use lies in conducting genetic analysis, specifically to understand inherited traits and genetic disorders. These Analyzers allow physicians to identify and evaluate genetic variations within an individual's DNA. This process can aid in making a diagnosis or determining a patient's predisposition to certain medical conditions.

Partnered with appropriate software, they perform capillary electrophoresis for the separation, detection, and analysis of labeled nucleic acids. These devices are an indispensable asset to any clinical laboratory involved in molecular diagnostic tests, including:
- Oncology: Identifying genetic mutations related to cancer.
- Pharmacogenomics: Understanding how a person's genetic makeup affects their response to drugs.
- Infectious diseases: Identifying pathogens by sequencing their genetic material.
- Genetic disorders: Diagnosing inherited diseases and conditions.

Variants identified can subsequently be used for genetic counseling, monitoring disease progression, and personalizing patient treatment plans. These analyzers allow for the precise and accurate generation of genetic data that is essential in modern medicine.

Summary


In conclusion, the Applied Biosystems™ 3500 Dx and 3500xL Dx Genetic Analyzers are powerful tools, providing essential genetic information that can help shape individualized treatment plans. They offer accurate, precise, and rapid sequencing abilities crucial to the diagnosis and management of various medical conditions. As technological and scientific advancements continue, their role in healthcare will only grow, thus making them an investment worth considering.


How It Works:

Introduction to Applied Biosystems™ 3500 Dx and 3500xL Dx Genetic Analyzers

The Applied Biosystems™ 3500 Dx and 3500xL Dx Genetic Analyzers are innovative tools in the world of diagnostic and clinical applications. These devices are designed to offer a broad dynamic range and optimal flexibility in terms of processing volume to accommodate varying laboratory requirements.

Working Principle

At the core of these genetic analyzers is the principle of capillary electrophoresis (CE), a proven methodology utilized in advanced genetic analysis. In a CE-based analysis, a gel-filled capillary tube is employed to separate DNA fragments based on their size. This is achieved by applying an electrical field along the length of the capillary tube.

Process Overview

The process involves an automated workflow subdivided into three main processes: 1. Sample Preparation: This initial stage involves the preparation of nucleic acid samples, such as DNA, in a suitable form. The DNA segments are then labeled with a fluorescent dye; each color corresponds to a specific nucleotide base – adenine (A), thymine (T), cytosine (C), and guanine (G). 2. Electrophoresis: Following sample preparation, the treated DNA sample is loaded into the capillary. The electrical field generated within the tube separates the DNA fragments. Smaller fragments are propelled through the gel at a quicker rate, creating a separation effect. 3. Detection: As each individual DNA strand passes through a laser-induced fluorescence detection window, the different base types are identified based on their specific fluorescent label.

Data Analysis

Finally, the software integrated into the Applied Biosystems Genetic Analyzer measures the fluorescence signal of each labeled DNA fragment and provides readable output indicating the sequence of bases in each respective fragment. This technology presents a comprehensive and valuable tool in genetic analysis or nucleic acid sequencing, aiding healthcare professionals in various diagnostics and genetic research.

Summary

Employing the compelling combination of capillary electrophoresis and fluorescence-based detection, the Applied Biosystems™ 3500 Dx and 3500xL Dx Genetic Analyzers serve as robust, reliable, and versatile platforms, assisting physicians and clinical researchers with high-resolution genetic analysis in a range of laboratory settings. The automation of the workflow and the ability to handle multiple samples simultaneously contribute to increased throughput, making these genetic analyzers an indispensable asset in the pursuit of advanced genetic analysis and personalized medicine.

Manufacturer:

Life Technologies Corporation


Status: In Stock


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